| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e16bd282bf65146da909ac92b80303f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 |
| filingDate |
2010-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_342e6fbf17c17b512bf7c7d3c73a17b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54e05eff290eb99e78be351cd46b8b3c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b19bf722beb73476829804056ba3610
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ca0feca25d55997812bc8d54aa5a721
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_169fa830c3f080af8dfd95d69a264545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_545f98a5be130d4331adb11b7a5ba3ea |
| publicationDate |
2010-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2758231-A1 |
| titleOfInvention |
Processes for the preparation of morphinane and morphinone compounds |
| abstract |
The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds. |
| priorityDate |
2009-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |