http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2751548-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_139aff3556869a0208383f5dac575e98 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-16 |
| filingDate | 2010-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2445e0135ba8105e07228d723416d14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7707d8e7c170157af86b45c63cc9e64e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc34cf756887b56432b938dd3b681f2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c2964b52fb1e5b9e400540f5ebf44ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce897b3b2c08aa84e1c3938d4fde130 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_331fcbf3a6a260b6ce2d2bd080045615 |
| publicationDate | 2010-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2751548-A1 |
| titleOfInvention | Synthesis of (4as,7as)-octahydro-1h-pyrrolo[3,4-b]pyridine |
| abstract | The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo [3, 4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo [3, 4-b]pyridine of formula (I) comprising : (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which Alk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro [3, 4-b]pyridine-5,7-dione of formula (IV) in which Alk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3, 4-b]pyridine of formula (I) with an optical purity above 99%. |
| priorityDate | 2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 155.