http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2750488-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b58f981963f6d55d627139e778c4ef7b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-20 |
| filingDate | 2010-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04160a4edecd396d70d290128b8f8644 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58863898bc5e411846d044a8970f8693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5f48c16da3219ca2bcee65c02f1815c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_911758092bec29a68718bfdffa55de8a |
| publicationDate | 2016-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2750488-C |
| titleOfInvention | Method for synthesis of (1s, 2r)-milnacipran |
| abstract | The present invention relates to a simplified method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran of the formula (I): comprising: (a) reaction of phenylacetonitrile and (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and by an acid treatment to obtain a lactone; (b) reaction of said lactone with MNEt2, wherein M represents an alkaline metal, or with NHEt2 in the presence of a Lewis acid-amine complex, to obtain an amide-alcohol; (c) reaction of said amide-alcohol with thionyl chloride to obtain a chlorinated amide; (d) reaction of said chlorinated amide with a phthalimide salt to obtain a phthalimide derivative; (e) hydrolysis of the phthalimide group to obtain (1S, 2R)-milnacipran, and (f) salification of (1S, 2R)-milnacipran in a suitable solvent system in the presence of a pharmaceutically acceptable acid. |
| priorityDate | 2009-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.