| abstract |
The present invention relates to morphine-6-glucuronide derivatives of following formula (I) in which: R1 is a 5-membered heteroaromatic group optionally substituted with one or several substituents chosen from among the atoms of halogen and (C1-C4) alkyl, halogen, hydroxyl, halo (C1-C4) alkyl, halo (C1-C4) alkyloxy, (C1-C4) alkyloxy, aryl (C1-C4) alkyl and aryl, said aryl group being optionally substituted by a or groups selected from groups (C1-C4) alkyl, halo (C1-C4) alkyl, hydroxyl and (C1-C4) alkyloxy, in basic form or addition salt with an acid and the hydrate state or solvate. The present invention also aims at their method of preparation and their application in therapeutics. |