| abstract |
The present invention relates to a method of making tert-butyl (R)-3-vinylpyrrolidine-1-carboxylate through the in-termediacy of one or more of diethyl (R)-2-(1-(tert- butoxycarbonyl)pyrrolidin-3-yl)malonate, (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)malonic acid, tert-butyl (R)-3-(2-hydroxyethyl)pyrrolidine-1 -carboxylate, and test-butyl (R)-3-(2-iodoethyl)pyrrolidine- 1-carboxylate. |