| abstract |
A method of manufacturing a medical construct comprises placing a length of cylindrical collagen gel about an outer surface of a support member before a winding step; allowing the cylindrical collagen gel to dry to form a film on the support member before the winding step; then winding at least one collagen fiber a number of revolutions over the cylindrical collagen film about a length of the support member having a long axis, the winding having at least one defined pitch and/or fiber angle relative to the long axis of the support member, while applying a liquid and/or gel of soluble collagen to a surface of the at least one fiber on the support member; and allowing the wound collagen fiber with the soluble collagen to dry; then applying a collagen gel over the dried collagen fiber with the soluble collagen and allowing the applied collagen to dry to form an outer layer of film to form the construct. |