| abstract |
The invention provides hereto-multivalent ligand binging agents (traps) for members of the TGF-.beta. superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hereto-multivalent binding agent with affinity for a member for the TGF-.beta. superfamily, said agent comprising the general structure (l): (<bd1 >-linker)k-[ {<bdl>-linker 2-<bd2>-linker 3f-}n -(<bd3>)m-(linker4-<bd4>)d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-.beta. superfamily, wherein at least two of bd1, bd2, bd3 , and bd4 are different from each other. |