| abstract |
The present invention provides for the use of a compound of formula (I): (see formula I) in which (a) n is 0, 1, or 2, m is 2, the two R1s together represent a 3',4'- methylenedioxy group, R2 and R3, together with the carbon atoms to which they are attached form a carbon to carbon double bond and, when n is 1 or 2, R4 and R5, together with the carbon atoms to which they are attached, form a carbon to carbon double bond and R6 is piperidino, or (b) n is 1 and (i) m is 3, two R1s together representing 3',4'- methylenedioxy and the other 6'-methoxy; or (ii) m is 2, the R1s being 3'- hydroxy-4'- methoxy; or (iii) m is 1 and R1 is 4'-hydroxy; and R2 to R6 are as defined in case (a) above, or (c) n is 1, R6 is isobutylamino or methoxy and R1 to R5 and m are as defined in case (a) above, or (d) n is 1, R4 and R5 represent hydrogen atoms and either R2 and R3 represent hydrogen atoms or R2 and R3 together with the carbon atoms to which they are attached form a carbon to carbon double bond; and m, R1 and R6 are as defined in case (a) above; and in all of which cases (a) to (d) any olefinic carbon to carbon double bonds are in the E geometric configuration, in the preparation of a medicament for the treatment of skin cancer. |