| abstract |
The invention relates to 2-alkyl-6-cycloamino-3- (pyridin-4-) derivatives. yl) imidazo [1,2-b] pyridazine, corresponding to the formula general formula (I) in which R2 represents a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-CM-alkyl, C 3-7 cycloalkyloxy-C 1-4 -alkyl-C 3-7 -cycloalkyl-C 1-4 -alkyloxy-C 1-4 -alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl; R3 represents a hydrogen atom or a substituent chosen from among the atoms of halogen and C1-3 alkyl groups, -NR4R5, hydroxyl or C1-4 alkyloxy; A represents a C-1-7-alkylene group optionally substituted with one or two groups R a; B represents a C1-7-alkylene group optionally substituted with an R b group; L represents either a nitrogen atom substituted by a group R c or R d, that is a carbon atom substituted with a group R e1 and a group R d or two groups R e2; R d represents a group selected from the hydrogen atom and the groups C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl; R f represents a C1-6-alkyl group, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 1-6 alkyloxy-C 1-6 alkyl, C 3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl-C1-4-C1-4 alkyloxy, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl. Preparation process and therapeutic application |