| abstract |
A pharmaceutical composition is provided which can easily be prepared and which can prevent decomposition of an aminoacetylpyrrolidine carbonitrile derivative, as an effective component, which derivative is in general instable in a pharmaceutical composition. More specifically, the pharmaceutical composition comprises an aminoacetyl pyrrolidine carbonitrile derivative represented by the following general formula (1): (see formula 1) (in the formula (1), A represents CH2, CHF or CF2; and R1 represents a secondary amino group which may have a substituent), and the following components blended with the derivative: (1) a sugar alcohol; (2) calcium carbonate, sodium citrate or sodium sulfate; and (3) a neutral low melting point oily and/or fatty substance. |