| abstract |
The present invention relates to piperazin-1-yl-trifluoromethyl-substituted-pyridines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these com-pounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disor-ders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. |