| abstract |
The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No 1, SEQ ID No 2, SEQ ID No 3 SEQ ID No 4, SEQ ID No 5 and SEQ ID No 6 or sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1(SEQ ID No 1), from 0 to 2 in CDR2(SEQ ID No 2), from 0 to 2 in CDR3(SEQ ID No 3), from 0 to 1 in CDR4(SEQ ID No 4), from 0 to 4 in CDR5(SEQ ID No 5), from 0 to 2 in CDR6 (SEQ ID No 6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No 1 to SEQ ID No 6. |