| abstract |
The invention provides functionalized polypeptides, especially therapeutic polypeptides (e g, scFv), comprising a linker sequence that can be rapidly and specifically functionalized by the addition of one or functional moieties (e g, PEG) or binding specificities (e g, an amino acid sequence with a particular binding specificity) Such functionalized polypeptides are ad-vantageous in that they have improved pharmacokianetic properties (e g, improved in vivo half-life, tissue penetration and tissue residency time) over non-functionalized polypeptides Methods for the rapid and reproducible generation of functionalized polypeptides are also provided. |