| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d7e470e09803bd6bf24b2fd176109dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2858411320fb0a2e0a846742666185f9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-445 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56905
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-80 |
| filingDate |
2009-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8b6eae2486fa35f3f0aa62a6c971ce2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0186fbdbf38ed3bdabadc7bdfd5d248c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_508d53857964cc87233b9c4eceb69246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79b2e6b81dd83fe24df875e0faf6ec85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06721cb09ff18c6d82d280ccef9ea803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ab9971f7ebec1a4c35d3eb09d238c1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dfcfb07359b9a9d858df14ff8d4e4e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1eb4dba08bbc3f192799ba35efdd76a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3741a29c3a52bcacf7a52799eccf910d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43161556d0a8b554d41e069964665c9d |
| publicationDate |
2009-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2726268-A1 |
| titleOfInvention |
Method for screening compounds for their ability to increase rigidity of red blood cells infected by a protozoan parasite of the genus plasmodium, method for filtering red blood cells, and application thereof. |
| abstract |
The invention relates to a method for screening compounds for their ability to increase rigidity of red blood cells (RBCs) infected by a protozoan parasite of the genus Plasmodium and in particular by Plasmodium falciparum. The present inven-tion also relates to a method for filtering RBCs that enables retention, in a filtering unit, of RBCs having an abnormal and in par-ticular a decreased deformability, as a surrogate for spleen filtering function. Said method enables in particular isolating and/or de-tecting Plasmodium- infected RBCs or spherocytes associated with acquired or hereditary spherocytosis from a sample of blood from a patient, or analysing in vitro spleen function of a patient. The invention also relates to the application of said methods, for the selection of compounds which selectively interact with iRBCs or selectively interact with ring-iRBCs and are suitable to in-crease their rigidity or to application of the method for filtering RBCs, for isolating and/or detecting RBCs with abnormal and es-pecially reduced deformability. This new filtration method is also amenable to automation and allows the clearance or concentra-tion of stiff RBCs, with wide experimental and medical applications in inherited or acquired RBC disorders (including malaria). |
| priorityDate |
2008-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |