http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2722316-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9bf7439808d578ab8c3698f7560fe4ab |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2009-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1c3229b87b5b5766e7f862d5ae2a279 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01624b85a08fb88d446c5206b4623cc9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2679bc105532c6c10ec64852dc8e77a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9a0360f2499290cd25cafe0f5afa587 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06c34c81f69c05befd951e0a34e7f5d2 |
| publicationDate | 2009-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2722316-A1 |
| titleOfInvention | Gene expression profiling based identification of genomic signature of high-risk multiple myeloma and uses thereof |
| abstract | The present invention discloses a method of applying novel bioinformatics and computational methodologies to data generated by high-resolution genome-wide comparative genomic hybridization and gene expression profiling on CD138-sorted plasma cells from a cohort of 92 newly diagnosed multiple myeloma patients treated with high dose chemotherapy and stem cell rescue. The results revealed that gains the q arm and loss of the p arm of chromosome 1 were highly correlated with altered expression of resident genes in this chromosome, with these changes strongly correlated with 1) risk of death from disease progression, 2) a gene expression based proliferation index, and 3) a recently described gene expression-based high-risk index. Importantly, a strong correlation was found between copy number gains of 8q24, and increased expression of Argonate 2(AG02) a gene coding for a master regulator of microRNA expression and maturation, also being significantly correlated with outcome. These novel findings significantly improve the understanding of the genomic structure of multiple myeloma and its relationship to clinical outcome. |
| priorityDate | 2008-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.