| abstract |
Provided are a five-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof, and a medicine containing the compound or salt. The compound or salt inhibits the infiltration of leukocytes such as eosinophils and lymphocytes, is effective as a therapeutic agent for various kinds of inflammation, and is so safe that the compound or salt can be taken for long. (see formula 1) In formula (1), R1 is (substituted) phenyl or pyridyl, R2 is (substituted) pyrazinediyl, pyrimidinediyl, or pyridazinediyl, R3 to R5 each is alkyl (provided that -N(R4)R5 may be morpholino), and Y2 is alkylene. |