| abstract |
Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan- associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associ-ated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods in-clude administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also pro-vided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions. |