| abstract |
The invention relates to the compounds of formula (I): (see formula I) in the form of a base or of a pharmaceutically acid addition salt acceptable, their use in therapeutic and their method of synthesis. In the formula (I), R 1 represents a heterocycle, for example a heteroaryl, eventually substituted; X represents from 1 to 4 identical or different substituents, one of the other being halogen, (C1-C10) alkyl, (C1-C10) alkoxy, NRaRb, nitro, or cyano, (C1-C10) alkyl being eventually substituted by one or more groups being halogen, (C1-C10) alkoxy, (C1-C10) halo, NRaRb or hydroxyl; R represents at position 3, 5, 7 or 8 of the imidazo [1,2-a] pyridine from 1 to 4 substituents identical or different from each other being hydrogen, halogen, (C1-C10) alkyl, halo (C1-C10) alkyl, or (C1-C10) alkoxy; R2 and R3 represent, independently one of the other, hydrogen, (C1-C10) alkyl optionally substituted with an Rf, group, or possibly aryl substituted; R4 represents hydrogen, optionally substituted (C1-C10) alkyl by an Rf group or optionally substituted aryl. |