| abstract |
The present invention relates to a controlled-release bead containing a pharmaceutically active ingredient. The controlled-release bead comprises a core made of a substantially water-insoluble inert material. A first layer is disposed over the core, with the first layer comprising a substantially water-soluble polymer. A second layer disposed over the first layer, the second layer containing the pharmaceutically active ingredient and a polymer. Finally, a third layer is disposed over the second layer, with the third layer comprising a controlling release polymeric system. The present invention also relates to dosage forms, such as tablets and capsules, comprising the controlled-release beads, and methods of manufacturing the controlled-release beads. |