| abstract |
The invention relates to compounds of formula (I): wherein A represents a bond, an oxygen atom or a group -O-CH2-; Ar represents a phenyl or heteroaryl group; Ar 2 represents a phenyl, heteroaryl or heterocycloalkyl; R1a, b, c and R2a, b, c represent a hydrogen atom or of halogen or an alkyl, cycloalkyl, -alkyl-cycloalkyl optionally substituted by one or more halogen atoms, OR5 (hydroxy or alkoxy), hydroxyalkyl, alkoxy-alkyl, alkoxy-alkoxy, haloalkyl, -O-haloalkyl, oxo, -CO-alkyl, CO-alkyl-NR6R7, -CO-haloalkyl, -COOR5, alkyl-COOR5, -O-alkyl-COOR5, -SO2-alkyl, -SO2-cycloalkyl, -SO2-alkyl-cycloalkyl, -SO2-alkyl-OR5, -SO2-alkyl-COOR5, -SO2-alkyl-NR6R7-SO2-haloalkyl, alkyl-SO2-alkyl, -SO2-NR6R7, - SO2-alkyl-O-alkyl-OR5, -CONR6R7, -alkyl-CONR6R7 or -O-alkyl-NR6R7, or R1a R1b, R1c are respectively bound to R2a, R2b, R2c and to the carbon atom that carries them and represent -O-alkyl-O-; R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen or halogen atom or a cyano group, -OR5, hydroxyalkyl, -COOR5, -NR6R7, -CONR6R7, -SO2-alkyl or -SO2-NR6R7, -NR6-COOR5, -NR6-COR5, -CO-NR6-alkyl-OR5; R5, R6 and R7 represent a hydrogen atom, a group alkyl or-alkyl-phenyl, and R8 represents an atom hydrogen, -SO 2 -alkyl or a group of formula -B-Het, where B may to be absent or to represent a bond, an atom of oxygen or a group -CO- or -SO2- (CH2) n with n equal to 0, 1 or 2 and where Het represents a heteroaryl or a heterocycloalkyl optionally substituted with alkyl, -SO 2 -alkyl and -COOR 5 groups. Preparation process and therapeutic application |