| abstract |
A novel scalable synthesis for the preparation of 7-(3--pyridinyl) -1,7-diazaspiro[4.4)nonane has been developed, and7-(3--pyridinyl) -1,7-diazaspiro[4.4]nonane salts have been formed with suc-cinic acid and oxalic acid. Additionally, 7-(3-pyridinyl)-1,7- diaza-spiro [4.4]nonane has been separated into its stereoisomers via resolu-tion with L and D di-p-toluoyltartaric acids, giving (R)- and (S)-7-(3-pyridinyl) -1,7-diazaspiro[4.4]nonane of high enantiomeric purity. Nu-merous solid salts of the resulting (R)- and (S)-7-(3-pyridinyl)-1,7-di-azaspiro [4.4}nonane have been prepared. Methods for the preparation of the racemic and enantiomeric salts, pharmaceutical compositions comprising such salts, and uses thereof are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders. |