http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2711444-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60d2134a44f2b4765a9a1a36828c1d8c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2009-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32bf3276a84c58802960c6c888be9f3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87d74902166e83903908b515e5316744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52290cc628cb832dc49ca9d52c117cf6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb1dde45639160dfb3a99b8721a6e0c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37b42c3bbc894a38916e398ad07975d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd1f26a6cd9aa7d2859b843f9ea2bae0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5c569ff536c83466aafa2320f3dae36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3fe35923d4563c9a07fe3b1d4309756 |
| publicationDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2711444-C |
| titleOfInvention | Method of synthesizing tetrahydrobiopterin |
| abstract | The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereo selectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g., sodium salts) in the aqueous solution after the hydrogenation reaction can be removed by contacting the aqueous solution with an ion (e.g., cation) exchange resin or column. Alternatively, removal of residual salts from the aqueous solution can be omitted if an organic amine (e.g., diethylamine or triethylamine) rather than an inorganic base is used in the hydrolysis and/or hydrogenation reactions |
| priorityDate | 2008-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.