| abstract |
The present application discloses oxadiazole based compounds of Formula (I) active on sphingosine-1-phos-phate (S1P) in particular useful to treat lupus erythematosus. A is phenyl or a 5 or 6-membered heteroaryl ring; R1 is up to two substituents independently selected from halogen, C(1-3 alkoxy, C(1-3 flyoroalkyl, cyano, optionally substituted phenyl. C(1-3 fluoroalkoxy. C(1-6 alkyl and C(3-6 Cyctoalkyl; R2 is hydrogen, halogen or C(1-4 alkyl; B is a 7 membered saturated ring selected from the following: Formulae (a) (b) (c) R3 is hydrogen or (CH2)1-4MC02H; R4 is hydrogen or C(1-3 alkyl optionally interrupted by oxygen; |