| abstract |
The present invention discloses diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of a hyperproliferative disorder such as hormone refractory prostate cancer. The invention includes a compound having the formula (see formula) where R1 and R2 together can include eight or fewer carbon atoms and can be selected from the group consisting of alkyl, substituted alkyl, and, together with the carbon to which they are linked, a cycloalkyl or substituted cycloalkyl group. R3 can be hydrogen, cyano, formyl, (see formula) R4 can be hydrogen, F, CI, Br, or I. R11 and R12 can be the same or different and are hydrogen or methyl. R13 can be hydrogen or -NR14R15. R14 and R15 can be the same or different and are hydrogen or methyl. Therefore 1-[(4-cyano-3-trifluoromethylphenyl)]-3-(4-substituted propylphenyI)-5-oxo-2-thioxoimidazolidine derivatives are disclosed and a process to make these derivatives, pharmaceutical compositions, and the medical use of such derivatives for the treatment of proliferative diseases such as cancer. |