http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2699454-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a7430b66a082478730221432ae79ca3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ee439ad400e6c078f83c23140d0b12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 |
| filingDate | 2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_230fccc29ed74e16732c5b602c170239 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_799d4bc92ea471e0704cc17d831a37d3 |
| publicationDate | 2009-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2699454-A1 |
| titleOfInvention | Methods for inhibiting tgf-.beta. |
| abstract | The present invention provides methods for inhibiting or blocking TGF-.beta. activity in cells and/or tissues expressing TGF-.beta. comprising, contacting cells and/or tissues expressing TGF-.beta. with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-.beta.. The present invention further provides a method for treating a condition associated with overactivity of TGF-.beta. or negative regulation in normal physiology by TGF-.beta. in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-.beta. in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-.beta. thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC. |
| priorityDate | 2007-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.