| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e09319fe979c0d63f50e0b9dcf132ae |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4707
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00 |
| filingDate |
2008-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8cf664c3522b8ebd9051adb168262cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e04508a77aaf049f15211795fa0d2d9f |
| publicationDate |
2009-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2697127-A1 |
| titleOfInvention |
Adeno-associated viral vectors for the expression of dysferlin |
| abstract |
The present invention provides a composition comprising: a first adeno-associated viral vector (AAV) comprising: i) an AAV 5'ITR (Inverted Terminal Repeat) sequence; ii) a portion of gene placed under the control of a promoter; iii) a sequence comprising a splice donor site; iv) a 3'ITR sequence of AAV; and / or a second adeno-associated viral vector (AAV) comprising: v) an AAV 5'ITR (Inverted Terminal Repeat) sequence; vi) a sequence comprising a splice acceptor site; vii) a portion of the gene; viii) a 3'ITR sequence of AAV. The joining of the gene portions carried by the first and second AAV vectors comprises an open reading frame that encodes a functional dysferlin. In addition, the joining of the sequence comprising the splice donor site and the sequence comprising the splice acceptor site contains all the elements necessary for splicing, advantageously derived from a native intron of the dysferlin gene. |
| priorityDate |
2007-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |