| abstract |
The invention relates to the novel compounds of formula (I): (see formula I) in which ---- represents a single or double bond; Ra represents H, Hal alkoxy, O-cycloalkyl, heteroaryl, phenyl, NHCOalk, NHCOcycloalk or NR1R2; X represents S, SO or SO2; A represents NH or S; W represents H, alkyl or COR with R is cycloalkyl; alkyl optionally substituted with NR3R4, alkoxy, hydroxy, phenyl, heteroaryl, or heterocycloalkyl; optionally alkoxy substituted by NR3R4, that is to say an O- (CH2) n-NR3R4 radical, an O-phenyl radical or O- (CH2) n-phenyl, with optionally substituted phenyl and n = 1 to 4; where the radical NR1R2; R1 is H or alk and R2 is H, cycloalkyl or alkyl; R3 and represent H, alk, cycloalkyl, heteroaryl or phenyl; R1, R2 and / or R3, R4 form with N a ring optionally containing O, S and N; all heterocycloalkyl, heteroaryl and phenyl and cyclic being optionally substituted; these compounds being in all isomeric forms and salts, as medicaments especially as MET inhibitors. |