| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f7b665fb8f15d0e2b0911539d39f8a2 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-267
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-267
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-27 |
| filingDate |
2008-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c2603d72b31b10dd120d358733b3abf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cf2cb7e6483e5e9ccd5e157d5827443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba599d3b6b284ff08376c5103ef9c3d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_debeef0d6bca8f121ffa4b0a04bdfc90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_257d4aff9ede005428dcf06fc3b1dfb7 |
| publicationDate |
2009-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2693843-A1 |
| titleOfInvention |
Process for the enantioselective preparation of pregabalin |
| abstract |
The invention provides a new enantioselective process for the preparation of (S) -pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) to obtain compound of general formula (II); oxidation of compound (II) to obtain a compound of general formula (III) and transforming compound (III) into compound of general formula (IV); subjecting compound (IV) to basic hydrolysis to obtain a compound of general formula (V) which is reduced to obtain enantiomerically pure S-pregabalin. The invention also provides new chiral intermediates involved in the process. |
| priorityDate |
2007-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |