| abstract |
The invention relates to 6-cycloamino-3- (pyridazin-4-yl) derivatives imidazo [1,2-b] pyridazine, of general formula (I) in which Ffe represents an optionally substituted aryl group; A represents a group C1-7-alkylene optionally substituted; B represents a C1-7-alkylen group optionally substituted; L represents either a nitrogen atom substituted by a group R c or R d, ie a carbon atom substituted with a group R e1 and a group R d or two groups R e2; the carbon atoms of A and B being optionally substituted with one or more, Rf groups identical to or different from each other; R7 and R8 represent, independently of one another, a hydrogen atom or a group C1-6-alkyl group. The invention also relates to method of preparation and their therapeutic application as inhibitors of casein phosphorylation for the treatment of sleep disorders, circadian rhythm disorders, diseases related to addiction or cell proliferation. |