| abstract |
Provided herein are novel sirtuin-modulating compounds and uses thereof. (see formula III) The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, insulin resistance, a metabolic syndrome, diabetes, or complications thereof as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |