Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16e694a83e0a87e09d92f0c1de5b4704 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
filingDate |
2010-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_426a8ad3094dccd3a8feb6fce1f462d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_767c288b2f805e9f01e17a48c18a25e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30d4c2a7f3bc13f67044c0b1ddd22442 |
publicationDate |
2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2691714-C |
titleOfInvention |
Determination of 5-asa efficacy in crc prevention and/or treatment by gene expression analysis |
abstract |
In one embodiment, there is provided an in vitro or ex vivo method for the determination of clinical responsiveness to prevention or treatment with 5-aminosalicylic acid (5-ASA) of a colorectal cancer in a mammal, the method comprising exposing for a period of time in vitro or ex vivo cells from the colorectal cancer or the mammal to 5-ASA, and measuring 5-ASA-induced upregulation of ยต-protocadherin and p21 waf-1, and optionally Kruppel-like factor 4 (KLF4) and CCAAT/enhancer-binding protein a (CEBP.alpha.), wherein upregulation determines the clinical responsiveness to 5-ASA. |
priorityDate |
2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |