| abstract |
Pharmaceutical compositions appropriate for the vaginal administration of steroids are described, to be used in a hormone replacement therapy, during menopause and to support the luteal phase of in vitro fertilization cycles. Compositions are characterized by the incorporation of polymers and disintegrators combinations, that allow an adequate mucous adherence and bio-availability of steroid hormones in the endometrium. This administration method reduces the systemic levels of steroids, allows a longer term in between doses, thus reducing side effects, and it prevents residues gathering inside the vaginal cavity. |