| abstract |
Disclosed are: a compound represented by the general formula (I); and oth ers. (I) wherein A1 and A2 independently represent a nitrogen atom or a meth ine group which may be substituted; the ring B represents a 5- to 7-membered aliphatic ring or a spiro or bicyclo ring formed by the aliphatic ring and a 3- to 7-membered aliphatic ring which is different from the aforementioned aliphatic ring; R1 represents a hydrogen atom, a C1-C6 alkyl group which ma y be substituted or an aryl, aralkyl or heteroaryl group which may be substi tuted; R2 represents an aryl, aralkyl or heteroaryl group which may be subst ituted; and X represents a group represented by the formula =NH or =O. The c ompound has an excellent cell proliferation inhibition activity relying on a Wee1 kinase inhibition activity and an additive/synergistic effect with oth er anti-cancer agent, and is therefore useful in the medical field. |