abstract |
Tetrahydroisoquinolin-1-one derivatives having an amide group at position-4 or a pharmaceutically acceptable salt thereof have an excellent antagonistic activity on a bombesin-2 (BB2) receptor. These compounds are also highly effective on stool abnormality. Therefore, these tetrahydroisoquinolin-1-one derivatives are useful as therapeutic agents for diseases associated with a BB2 receptor, particularly IBS. |