http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2685746-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03dbd4a28db5f9da3f2809b3d31f66cc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 |
| filingDate | 2008-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_763aacdba1cd5770e1cbc557b9f641bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57091734fafc656d2bd6fc501df52bf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f911e7a9f5779f9f7b1663999e428a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67cd010e61803bdf7d60ca9434b7843e |
| publicationDate | 2008-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2685746-A1 |
| titleOfInvention | In vitro model of latent mycobacterial infection |
| abstract | A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it to multiple stress conditions, including a low nutrient culture medium without glycerol, a low pH, a relatively high level of carbon dioxide and a relatively low gas phase oxygen level. An in vitro model of mycobacterial infection employs macrophages induced from THP1 cells which are then infected with Mycobacterium. The infected macrophages are grown under hypoxic conditions to induce latency in the mycobacteria. The in vitro model of infection is useful in evaluating compounds for activity against latent mycobacteria. |
| priorityDate | 2007-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 283.