| abstract |
The current invention describes chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula (VIII) in which at least one of the groups X1, X2, X3 is selected from fluoro, chloro, bromo, hydroxy, methoxy, ethoxy, trifluoromethyl, amino whereas the other groups X1, X2, X3 have the meaning of a hydrogen atom, in which at elast one of the groups Z1, Z2, Z3 is selected from -O-, -S-, -NH-, -N(-CH3)-. wheras the other groups Z1, Z2, Z3 have the meaning of a -CH2- group, and in which Ar is an aromatic group. (See formula VIII) |