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filingDate 2008-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cb025d2280002ec4e16aaeab0dee798
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3088d38d84d011ca7df4818408c5ec9
publicationDate 2008-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2682948-A1
titleOfInvention Methods of evaluating cells and cell cultures
abstract Methods of evaluating the composition of a cell culture (e.g., to distinguish chondrocytes from fibroblasts) and methods for evaluating the phenotype of an individual cell (e.g., as a chondrocyte) are disclosed. The methods may be used, for example, for assessing chondrocyte cultures used for treatment of cartilage defects. In some embodiments, the invention involves identifying cell culture composition or the identity of a cell based on expression level of a fibroblast marker. In other embodiments, the invention involves comparing expression levels of at least one chondrocyte marker and at least one fibroblast marker in a cell culture sample or in an individual cell. In illustrative embodiments, the chondrocyte marker is hyaluronan and proteoglycan link protein 1 (HAPLN1 ), and the fibroblast marker is microfibrillar associated protein 5 (MFAP5).
priorityDate 2007-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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