| abstract |
The invention relates to pyrrolidine derivatives of formula (I) wherein R1 is hydrogen, halogen or lower alkyl; R2 is hydrogen, halogen, lower alkoxy or lower alkyl substituted by halogen; R3 is -(CH2)p-heterocyclyl optionally substituted by lower alkyl, halogen, -S(O)2-lower alkyl, -C(O)-lower alkyl, -C(O)O-lower alkyl, hydroxy, lower alkyl substituted by hydroxy, -(CH2)p-O-lower alkyl, -NHCO-lower alkyl, or is C3-6-cycloalkyl optionally substituted by =O, -(CH2)p-O-lower alkyl or lower alkinyl, or is unsubstituted or substituted aryl or heteroaryl, wherein the substituents are selected from the group consisting of lower alkyl, CN, -S(O)2-lower alkyl, halogen, -C(O) -lower alkyl, hydroxy, lower alkoxy or lower alkoxy substituted by halogen; or is -(CH2)P-NR4R5; R4/R5 are independently from each other hydrogen, lower alkyl, -(CRR')p-lower alkyl substituted by hydroxy, -(CRR')p-O-lower alkyl, -(CRR')p-S-lower alkyl, -(CRR')p-O-lower alkyl substituted by hydroxy or C3-6-cycloalkyl; R/R' are independently from each other hydrogen, lower alkyl or lower alkyl substituted by hydroxyl; n is 1 or 2; o is 1 or 2; P is 0, 1, 2, 3 or 4; or to pharmaceutically active acid-addition salts thereof. |