http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2671961-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c59f8c3e9036d07b6347d106f7762f14 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
filingDate | 2007-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7de3976bb7e5a5a73eb368ce61370db6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fffac34b472a8d78fcbe39c2f0bb53c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcc63f6c0f725783097c1133a3a4eb62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1bfa34226191df88785be8002524c59 |
publicationDate | 2008-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2671961-A1 |
titleOfInvention | Enhanced retinal delivery of a nucleic acid through iontophoresis |
abstract | The present invention provides a device and a method for the enhanced retinal delivery of nucleic acid therapeutics utilizing iontophoresis to evoke a transient elongation of the Muller Cells of a mammalian eye. The enhanced retinal deposition can be achieved by either a topical application, subconjunctival, or an intravitreal injection of the nucleic acid composition followed by, preceded by, or administered simultaneously with the iontophoretic application. The present invention thus provides a particularly advantageous method for the treatment of ocular diseases comprising the in vivo administration of a nucleic acid capable of alleviating the symptoms of a disease, the delivery of the nucleic acid being enhanced by using iontophoresis. This method can be applied particularly to the diseases of the retina resulting from an alteration of a gene expression and/or the over-expression of particular growth factors. The diseases include, but are not limited to, human ocular retinopathies including, neovascular diseases (Age-Related Macular Edema, Diabetic Retinopathies, Diabetic Macular Edema, etc.) and inherited retinopathies such as retinitis pigmentosa. |
priorityDate | 2006-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1312.