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filingDate 2007-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a49a0ac2372ee5fd78fa9ca2d74e744
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publicationDate 2008-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2671159-A1
titleOfInvention Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration
abstract Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The method ology utilizes either magnetic resonance images or combined magnetic resonan ce and computed tomography images as a template for creating either the inte rvertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffo ld) with fixation to the underlying bone. The disc scaffold design may inclu de an outer annulus that may contain desired structures and a central nucleu s pulposus region that could either contain a designed microstructure or a c ontained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different mic rostructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The scaffolds a re designed with a microstructure that controls elastic and permeability pro perty distribution within the scaffold.
priorityDate 2006-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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