http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2661669-A1

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filingDate 2007-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f775eb5bcb628e49558f3209414de2e2
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publicationDate 2008-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2661669-A1
titleOfInvention A pharmaceutical composition for treating cholangiocarcinoma, a method for inhibiting growth or invasion of cholangiocarcinoma and a method for treating cholangniocarcinoma
abstract Disclosed herein are a pharmaceutical composition for inhibiting the growth or metastasis of cholangiocarcinoiria, comprising a LlCAM activity inhibitor or expression suppressor and a treatment method using the composition. This is based on the finding that LlCAM is overexpressed on cholangiocarcinoma and plays an important role in the growth and metastasis of cholangiocarcinoma and the mortality of cholangiocarcinoma patients increases as the expression rate of LlCAM increases. Also, antibodies inhibitory of the activity of LlCAM, or siRNAs suppressing the expression of LlCAM, are found to reduce the growth and invasion of cholangiocarcinoma cells. Mouse monoclonal antibodies, recognizing the LlCAM protein on the cholangiocarcinoma cell surface and binding specifically to cholangiocarcinoma tissues, or siRNAs, antisense oligonucleotides or shRNAs, may be useful in the treatment of cholangiocarcinoma by inhibiting the growth, invasion and migration of cholangiocarcinoma cell.
priorityDate 2006-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID404306
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP24314
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Y691
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5QTU8
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID177161
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0DF14
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5RD49
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8H1C7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0DF15
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1JMX4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A7Y0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1C7M6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A7Y1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9NRR4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0TXH8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7GGE9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A7Y2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8GYE2
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID37290
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01132
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP15873
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3P5Q0
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID25313
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5UBC4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8KAN7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP57761
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7FFT9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0HSJ1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8EH81
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP70059
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6F1N5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID378478
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID41393035
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6YPW7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP23916
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1209413
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3AC58
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8GQT8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7MIQ2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9JC73
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ92R47
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9A805
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1956
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ39T82
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1AE97
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP56118
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC6DC00
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2YN02
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4FUV6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8K9R1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP12004
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7X1J9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ608M7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9WJ69
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID33061873
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID61602532
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1JI19
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1950
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ83I82
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5PIG5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID408035
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1403881
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ07YZ6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Y0I1
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID36289
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP00764
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6YQI6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP00775
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3A4Q8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3K1Y2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ17XJ6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2FHK5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BNJ5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID45426913
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403045
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID24775
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1JCZ9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5YS08
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7M8I0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCE2R0D6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ92JB0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP35034
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4FLS9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ88WK0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0TIV7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP35048
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID887873
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6J4J9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4Y4K4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8E680
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9VT87
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4835991
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB4RJT7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ667V1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0TGW4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8EBQ2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3MZQ9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0HG98

Total number of triples: 719.