http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2659747-C

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
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filingDate 2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61b613ee35233978e44c1f945b0b468c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f3f884fca8812d79b74780384abbd4a
publicationDate 2015-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2659747-C
titleOfInvention Non-flushing niacin analogues, and methods of use thereof
abstract One aspect of the present invention relates to substituted pyridines and pharmaceutically acceptable salts thereof that are active against a range of mammalian maladies. The compounds are represented by structure A, or a pharmaceutically acceptable salt thereof: (see structure A) another aspect of the invention relates to a pharmaceutical composition, comprising a compound of the present invention or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient. The present invention also relates to methods of treating a range of mammalian maladies or conditions, including but not limited to hyperlipidemia, hypercholesterolemia, atherosclerosis, coronary artery disease, congestive heart failure, cardiovascular disease, hypertension, coronary heart disease, angina, pellagra, Hartnup's syndrome, carcinoid syndrome, arterial occlusive disease, obesity, hypothyroidism, vasoconstriction, osteoarthritis, rheumatoid arthritis, diabetes, Alzheimer's disease, lipodystrophy, or dyslipidemia, raising serum high-density lipoprotein (HDL) levels, and lowering serum low-density lipoprotein (LDL) levels.
priorityDate 2006-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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