| abstract |
The invention provides the use of a glucocorticoid receptor antagonist for the manufacture of a medicament for immune stimulation, such as prevention or treatment of infections or infectious conditions, in an aging mammalian subject, a mammalian subject with low serum DHEAS v a l u e s, a mammalian subject with a high serum cortisol/DHEAS ratio or a mammalian subject with high neutrophil counts. In particular, the glucocorticoid receptor antagonist can be chosen from the group consisting of a dibenzopyranyl derivative defined and/or exemplified in US6329534 and WO200116128, mifepristone, and (11.beta.,17.beta.)-11-(1,3-benzodioxol-5- yl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one. |