http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2656273-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2fde8151c4e5563776c31e4e65c98feb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N2005-1094 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 |
| filingDate | 2007-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6255a15ab577721129119729fcfba4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56bb5b55418e01a9b43ceb18acfa6a95 |
| publicationDate | 2008-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2656273-A1 |
| titleOfInvention | Prevention of nuclear, solar, and other radiation-induced tissue damage |
| abstract | Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis IP-6 also activates DNA repair mechanisms Sublethal radiation causes DNA 5 damage through the fonnation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis IP-6 and/or inositol and their pharmaceutically acceptable salts and de.pi.vatives, including pyrophosphates and citrate derivatives, significantly counteract the harmful effects of radiation, affecting cell cycle progression in a protective manner (more cells in the protective Gl phase) as well as decreasing apoptosis and caspase-3 activation Vanous salts of IP-6 are used with 15 comparable efficacy and the combination of IP-6 + inositol affords the best protection against radiation-induced cell injury Thus IP-6 and inositol are effective agents for protection against nuclear, solar and other radiation injuries. |
| priorityDate | 2006-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 600.