http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2649073-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e94d1e7406946f6249f41142a96cd821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fc0cd4ef0fbf4b87eb0c5a45c0df1cc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2007-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8159046c2c392749fc8ef90338a38822 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e31e2cc53a14885472c8d464bfa49e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22b9b36f6891c58d515812ae2bf34880 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4c323474926c25c92c70d58eae3908a |
| publicationDate | 2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2649073-A1 |
| titleOfInvention | Compositions and methods for suppression of amyloid plaque formation associated with neurodegenerative disorders |
| abstract | The invention provides a method for reducing or inhibiting net beta-amyloid peptide production and amyloid plaque formation associated with Alzheimer's Disease by administering to a subject an amount of a netrin-1 polypeptide, wherein the netrin-1 polypeptide comprises an amino acid sequence that a) binds to a naturally occurring APP protein and b) inhibits A.beta. peptide production. A netrin-1 polypeptide has an amino acid sequence sufficient for specific binding of the netrin-1 polypeptide to the APP protein. A netrin-1 polypeptide can mimic netrin-1 -mediated signal transduction by altering the localization, protein-protein binding and/or enzymatic activity of an intracellular protein involved in an APP signal pathway. The invention also provides a method for reducing or inhibiting amyloid plaque formation associated with Alzheimer's Disease by administering to a subject an amount of a netrin-1 therapeutic, wherein the netrin-1 therapeutic comprises an amino acid sequence that a) binds to a naturally occurring APP protein and b) inhibits A.beta.peptide production. |
| priorityDate | 2006-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.