http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2632437-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b071176d1f0558a78a2a65f85f5f523 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 |
| filingDate | 2006-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be1b9fc4f2f5481c5d1a2f1769c91535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a60f2da2a97b5b77c0c1712c1eb0d0bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04385a1e0818c55ca2d26112047c6f72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b150c36b83ea6b8cf81feb5def01614a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b62b9250d84f591363a0fcd6ef6d43bc |
| publicationDate | 2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2632437-C |
| titleOfInvention | 1,2,4-triazol-1-yl bisphenyl derivatives for use in the treatment of endocrine-dependent tumours |
| abstract | There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and -Y-R6; wherein each R8 is independently selected from -OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (-CN), nitro (-NO2), H-bond acceptors, and halogens; wherein at Jeast one of R3, R4, R5, R6 and R7 is -Y-R8 wherein R8 is selected from substituted and unsubstituted ~ heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further , substituted; wherein R9 is selected from H, -OH and -OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is -Y-R8; OR (b) R9 is -OSO2NR1R2 or - OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is -Y-R8. These compounds inhibit steroid sulphatase and aronatase activity and are useful in the treatment of endocrine-dependent tumours. |
| priorityDate | 2005-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 478.