http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2631951-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caec7099b724bb45d2518787825aab94 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-32 |
| filingDate | 2006-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ada3f49ccdb4b798415cab5a8bff26e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5376f53a4ef2efdb7ddbe56b3886351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef54fb7c5fd54705a6a0e92e5df874cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bac1221f2dc56d23a8784686965acc77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c24aa666008cf7b4bf6544dcb8680a14 |
| publicationDate | 2007-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2631951-A1 |
| titleOfInvention | A manufacturing process of 2',2'-difluoronucleoside and intermediate |
| abstract | The present invention relates to more improved process for preparing 2'-deoxy-2',2'-difluoronucleoside and its intermediate. The present invention provide a process for preparing an erythro enantiomer in greater than 98% purity, comprising forming a lactone ring by hydrolyzing ethyl (3RS )-2,2-difluoro-3-hydroxy-3-(2,2-dimethyloxolan-4-yl)propionate is hydrolyzed in the presence of hydrolysis reagents selected from acetic acid or chloroacetic acid, water and a mixture of organic solvents selected from the group comprising acetonitrile, dioxane, tetrahydrofuran or toluene, in¬ troducing a substituted benzoyl protecting group at the 3-position and 5-position, and recrys- tallizing said erythro enantiomer. Further, the present invention provides a process for selectively preparing, in greater than 99% purity, a beta-anomer 2'-deoxy-2',2'-difluoronucleoside at the 3'-position and 5'-position that are protected by a substituted benzoyl in a 2:3 alpha/beta anomeric ratio. |
| priorityDate | 2005-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.