http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2629720-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65f6765a6f0387cfcb75bc6a09213161 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-32 |
| filingDate | 2006-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e598ffb71fd24858f64150f7b1bea025 |
| publicationDate | 2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2629720-A1 |
| titleOfInvention | Synthesis and preparations of intermediates and polymorphs thereof useful for the preparation of donepezil hydrochloride |
| abstract | The invention relates to a process for preparing 2- (l-benzylpiperidin-4-ylmethyliden) -5, 6-dimethoxyindan-l-one (a key intermediate in the synthesis of donepezil hydrochloride), crystalline polymorph forms of this key intermediate and their use thereof for producing donepezil hydrochloride. In particular, the invention provides a method for producing the intermediate 2-(l -benzylpiperidin-4-ylmethyliden) -5, 6- dimethoxyindan-1-one. The process includes reacting 5, 6-dimethoxyindan-l-one with l-benzylpiperidine-4-carbaldehyde using potassium hydroxide in an aqueous solvent. The aqueous solvent can be a mixture of an organic solvent and water. Where the organic solvent is not miscible with water, the reaction may be performed in the presence of a phase transfer catalyst. |
| priorityDate | 2005-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.