| abstract |
Compositions and method for the minimization or prevention of adhesion formation, whereby an effective amount of at least one lazaroid compound, preferably one of general formula (I), wherein R represents a formula (Ia) or (Ib), or formula (II), wherein R represents H or CH3; R1 represents formula (Ia) or formula (IIa), wherein R2, R3, R4, and R5 independently represent H or NR6R7, wherein R6 and R7 independently represent H and C1-C6 alkyl is administered for a period of time sufficient to permit tissue repair. The compound of general formulae (I) or (II) is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the compound at an effective level. |