| abstract |
An anti-IL-6 receptor antibody is examined on its inhibitory effect against transplanted islet dysfunction produced after islet transplantation. As a result, it is found that the anti-IL-6 receptor antibody can reduce the transplanted islet dysfunction, improve the survival of the transplanted islet, and also improve the hyperglycemic state of a recipient. It is also found that administration of the anti-IL-6 receptor antibody enables to prevent the production of an inflammatory cytokine in an infiltrating cell after the transplantation. Thus, it is now found that transplanted islet dysfunction produced after islet transplantation can be prevented by using the anti-IL-6 receptor antibody. |